Mice infected neonatally with homogenates from lymphomas induced by the Moloney virus showed a deficient or delayed antibody response, measured by the indirect fluorescent antibody test against Moloney lymphoma target cells in comparison with mice infected as adults. In neonatally infected mice there was a correlation between the development of antibodies and the length of the preleukemic latency period.

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This work was supported by research grants from the Damon Runyon Memorial Fund (DRG-598), the Jane Coffin Childs Memorial Fund for Medical Research, the Swedish Cancer Society, and Knut and Alice Wallenberg's Foundation.

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