Single, nonlethal doses of hydroxyurea are rapidly inhibitory to the incorporation of thymidine-2-14C and phosphate-32P into DNA2 of regenerating liver of the rat. The agent does not affect synthesis or sedimentation profiles of RNA, and it is not cytotoxic to liver under the conditions tested.


This research was supported by Grant CA-03192 from the National Cancer Institute, USPHS.


The following abbreviations are used: DNA, deoxyribonucleic acid; RNA, ribonucleic acid; TCA, trichloroacetic acid; Tris, tris(hydroxymethyl)aminomethane; SDS, sodium dodecylsulfate; ND, naphthalene disulfonate.

This content is only available via PDF.