A method has been devised for maintaining an extensive cross-circulation between two rats for periods of up to 48 hours. When one of the partners in such a cross-circulation was partially hepatectomized compensatory hyperplasia took place in the remaining fragment of liver but not in the liver of its intact partner.

When single rats were subjected to partial hepatectomy the pressure in the portal vein showed a slight and transient increase and returned to about the pre-operative value within 24 hours.

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