Several transplantable mouse and rat tumors were injured in a reproducible manner by implanting a length of cotton thread in their substance. Normal tissues, including liver, spleen, kidney, and subcutaneous connective tissue, were treated similarly. At the end of 1 week tissues containing thread were removed for histologic study. Consistently, the inflammatory response to the foreign body within the neoplasms was minimal as compared with the normal tissues. Although the tumors varied considerably in architecture and origin, differences in inflammatory response among the tumor types were not evident. A rapidly growing nonmalignant tissue, regenerating liver after partial hepatectomy, responded like the normal tissues after 7 days' exposure to the thread.

The response of one of the tumors, the mouse gastric Adenocarcinoma 328, was studied at various intervals, from 1 day to 23 days. Through this period the response within the tumor and that within subcutaneous connective tissue followed the usual sequence of inflammatory events but was always minimal in the tumor.

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Presented in part before the American Association for Cancer Research, Atlantic City, New Jersey, April 7, 1961. Supported by Research Grant C-2800 from the Public Health Service.

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