The mechanism of formation of a transplantable ascites tumor was studied to observe the origin of tumor cells free in the peritoneal cavity. The development of the ascites tumor was observed to proceed by an initial penetration of tumor cells into the mesentery and retroperitoneal organs within the first day, their proliferation within these structures, and subsequent exfoliation into the fluid accumulating in the peritoneal cavity.

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This study was supported in part by a research grant, CY-3654, from the National Cancer Institute, National Institute of Health, Bethesda, Maryland.

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