Specific antigen was detected in the bovine cutaneous papilloma by fluorescent-labeled antiserum prepared against an infectious extract of bovine papilloma. Antigen was present in the nuclei of cells in the keratohyaline and keratinized layers of the hyperplastic epithelium but not in the germinal basal cells. These findings are similar to those reported for the Shope rabbit papilloma and the human cutaneous papilloma.

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Published with the approval of the Director of the Wisconsin Agricultural Experiment Station. Supported in part with the aid of RG, C4627 National Institutes of Health. The technical assistance of Miss Margaret K. Wilson and the help of Drs. D. F. Brobst and A. J. Luedke in collecting papilloma tissues are gratefully acknowledged.

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