A marked and progressive decrease in epidermal hydroxyproline accompanied induced epidermal carcinoma by methylcholanthrene in C3H mice. A decrease was also noted in the benzene-treated controls; but this was reversible, whereas the effect produced by the carcinogen was not. A progressive increase in epidermal tyrosine was observed which was more marked in the carcinogen-treated animals than in the controls. Acid hydrolysates of the carcinogen-treated skins produced a darker, humin-like coloration than did those of the controls. The possible origin of this is discussed. The results are interpreted in terms of the sensitivity of fibroblasts to methylcholanthrene.


Presented on September 15, 1960, at the 138th annual meeting of the American Chemical Society, New York, N.Y.

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