Extracts prepared from Walker carcinosarcoma 256 or Flexner-Jobling carcinoma, when injected into normal rats, resulted in a decreased concentration of plasma iron, liver and kidney catalase activity, and increased liver and spleen weights. Rats bearing these tumors showed similar measurable changes when the tumor was less than 5 per cent of the total body weight. Extracts prepared in the same manner from either the Jensen sarcoma or Novikoff hepatoma significantly altered only the spleen weight and plasma iron, changes which also occurred in the host during the early periods of growth of these tumors.

While extracts or homogenates of normal tissues also produced some of these effects, the amount of normal tissue required was greater than the amount of tumor tissue needed to produce a comparable effect.

This content is only available via PDF.