Transplantation studies revealed that a human epidermoid carcinoma, H.Ep. #3, can grow in conditioned adult dogs; but toxic, or near-lethal, doses of x-radiations and cortisone are required for transplants to grow. Because of these limitations, cortisone treated and x-radiated adult dogs bearing human tumor transplants are not amenable for long-term experimental chemotherapy studies.
This study was supported in part by: Research Grant CY-3784 from the National Cancer Institute, Public Health Service; Contract SA-43-ph-1923 from the Cancer Chemotherapy National Service Center, Bethesda, Md.; and in part by Grant T-47 from the American Cancer Society, Inc., New York, N.Y.