Liver catalase activity in rats bearing a transplanted lymphocytic leukemia showed progressive changes that were similar to those reported for solid neoplasms in a rodent. There was an initial drop in the recipient's liver catalase activity upon inoculation with blood from a leukemic donor. This was followed by a return to normal liver catalase activity levels and then by a further steady decline until the animal died. The early changes took place before there was any visible evidence of tumor growth either in the liver or elsewhere in the body.


This investigation was supported by Grants C-3562, C-4659, CRT-5022, and SF-4 from the National Institutes of Health, United States Public Health Service.

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