The behavior of hamster melanoma after homologous transplantation to different sites has been studied. The relationship between transplanted tumor size, gross metastases, and circulating tumor cells was recorded. The variability of the heterotransplants, depending on the site of transfer and recipient animal, was noted. The following observations were made:

The hamster melanoma was readily transplantable to all attempted sites in the hamster. There was some tendency toward sarcomatous transformation upon homologous transplantation of the hamster melanoma. In hamsters bearing malignant melanoma transplants, circulating tumor cells in the blood stream could be detected only after gross metastases had appeared.

Heterologous transplantation was accomplished in the subcutaneous space of Swiss mice, peritoneal cavity of the guinea pig fetus, and the anterior chamber of guinea pigs' eyes.

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This work was supported by grants from the American Cancer Society, Louisiana Division, Cancer Teaching Grant CT 762 (C10) from the National Cancer Institute of the National Institutes of Health, and the Anna Fuller Fund for Medical Research.

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©1960 American Association for Cancer Research.
1960
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