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In the first study the term “initiation” was defined and used to imply “the conversion of normal tissue to malignant tissue without consideration of the intermediary phases.” Since then, the work of Rous and his associates (4, 6) and of Berenblum (1), as well as our own work (unpublished), clearly indicates that “genesis” or “formation” is a better term for the over-all changes that result in a perceptible tumor. Therefore, the words “initiation” and “inception” will be applied only to those transformations that render cells neoplastic, without consideration of subsequent changes.

This investigation was aided by a grant from the National Cancer Institute.

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