Summary
The effect of virus infections upon chicks bearing metastatic human epidermoid carcinoma (H. Ep. #3) was investigated. Bunyamwera, Bwamba, Mengo, Russian, and Semliki Forest viruses showed no evidence of antitumor effect in this system. Uganda caused a slight but statistically insignificant increase in survival. Egypt 101 (West Nile) virus, after serial passage through tissue cultures of the H.Ep. #3 cell, caused slight increases in survival and in frequency of tumor regressions. Although statistically significant, this apparent oncolytic effect must be accepted with caution in view of the many variables in this experimental system. Egypt 101 virus, which was propagated in mouse brain or serially passaged through tissue cultures of H.Ep. #2 cells, had no oncolytic effect.
Studies of the distribution of Egypt 101 virus indicated that virus was present in high titer in the tumors longer than in normal tissues of tumor-bearing or normal chicks.
There was no relationship between size of the tumors on the chorioallantoic membrane and time of chick death and only a slight inverse correlation between size of tumor on the membrane and time of appearance of metastases.
Studies supported in part by grants from the U.S. Public Health Service, National Institutes of Health; the Ford Foundation; and the P. Waterman Fund.
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