1. The uricase activity of livers of tumor-bearing mice diminished with increasing tumor growth more slowly and ultimately less extensively than did the catalase activity. There was apparently no effect on the intracellular distribution of either enzyme.

  2. Injection of 3-amino-1,2,4-triazole had no effect on uricase under conditions in which the liver catalase was reduced essentially to zero.

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Work performed under the auspices of the U.S. Atomic Energy Commission.

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