1. Perthane, fed to C3H unbred female mice in a maximum tolerated dosage for life, prevented the formation of spontaneous mammary carcinoma in all animals treated.

  2. No direct anti-tumor effect could be demonstrated in studies of transplanted mammary carcinoma in the C3H mouse.

  3. Decreased ovarian size, depressed corpus luteum activity, as well as uterine and vaginal epithelial atrophy occurred in animals treated for long periods. No evidence of adrenal cortical hypoplasia or hyperplasia could be demonstrated histologically in animals receiving Perthane in our experiments.

  4. Possible mechanisms of the action of Perthane are discussed.

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This research was supported in part by grant CT 496 of the National Cancer Insitute of the National Institutes of Health, Public Health Service; and the facility of the Samis Grotto Cancer Research Laboratory, Medical College of Virginia.

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