The effects of hormone administration on the growth, morphology, and secretion of a transplantable mouse granulosa-cell tumor were studied.

The percentage of takes, average latent period, average growth rate, and average survival time were not influenced when the tumor was transplanted into hosts with estrogen-inhibited pituitary gonadotrophin secretion. This indicated that establishment and growth of the tumor were not dependent upon the pituitary gonadotrophin of the host.

Massive doses of equine-serum gonadotrophin and chorionic gonadotrophin did not cause luteinization or any morphological responses in the tumors.

When ovariectomized hosts were carrying the tumor, their uterine weight and morphology indicated that the tumor was secreting ovarian hormones. The uterine weight and morphology of ovariectomized, gonadotrophin-treated mice bearing tumors indicated that this hormone would cause an increase in tumor estrogen secretion.

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This investigation was supported in part by Grant C-2246 M & G from the National Cancer Institute, U.S.P.H.S. A preliminary report on this study was made at the meeting of the American Association for Cancer Research, April 15–17, 1955 (Proc. Am. Assoc. Cancer Research, 2:20, 1955).

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