1. The cytopathogenic effects of rabbit and chicken anti-HeLa sera have been described. The action of the antisera was observed on HeLa cells, normal human cells, and a mouse mammary carcinoma in tissue culture.

  2. Rabbit and chicken anti-HeLa sera were shown to be cytotoxic for a variety of human tissues and not specifically directed against HeLa cells.

  3. Anti-HeLa serum, under the conditions described, had no effect on the in vitro growth of a mouse mammary carcinoma.

  4. The efficacy of rabbit cytotoxic antiserum upon HeLa cells “in vivo” has been demonstrated.


Supported in part by a grant-in-aid from the American Cancer Society upon recommendation of the Committee on Growth of the National Research Council administered by C. M. Pomerat and in part by a research grant from the Damon Runyon Memorial Fund for Cancer Research.

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