The cytopathogenic effects of rabbit and chicken anti-HeLa sera have been described. The action of the antisera was observed on HeLa cells, normal human cells, and a mouse mammary carcinoma in tissue culture.
Rabbit and chicken anti-HeLa sera were shown to be cytotoxic for a variety of human tissues and not specifically directed against HeLa cells.
Anti-HeLa serum, under the conditions described, had no effect on the in vitro growth of a mouse mammary carcinoma.
The efficacy of rabbit cytotoxic antiserum upon HeLa cells “in vivo” has been demonstrated.
Supported in part by a grant-in-aid from the American Cancer Society upon recommendation of the Committee on Growth of the National Research Council administered by C. M. Pomerat and in part by a research grant from the Damon Runyon Memorial Fund for Cancer Research.