Adrenocorticotrophin given to male mice of strain C57BL over a period of 5 months at various periods of life caused an increase in the incidence of malignant lymphoma. The highest susceptibility to ACTH-induced lymphoma was observed in animals in which hormone treatment was begun during the period of growth.

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The investigation was supported by Research Grant A 22(C4) from the National Institute of Arthritis and Metabolic Diseases of the National Institutes of Health, Public Health Service.

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©1955 American Association for Cancer Research.
1955
Cancer Research, Inc.