Amblystoma punctatum embryos reared in a 1 mg. per cent aqueous solution of the crystals of Lathyrus odorata developed tumors of the notochord. The histologic appearance of these tumors is described. Two possible mechanisms of pathogenesis of these lesions are discussed. The suggestion is made that these tumors arise as a consequence either of a focal degeneration of the notochord sheath, leading to secondary proliferative ecchordoses or prolapses, or of a direct stimulation to proliferation of the notochordal cells.

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Supported in part by a grant-in-aid from the United States Navy, Office of Naval Research, Nonr 266(15), and in part by the Orthopedic Research Fund through Dr. Alan de Forest Smith.

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©1955 American Association for Cancer Research.
1955
Cancer Research, Inc.