Discs of skin of total skin thickness were removed from the backs of rabbits. The wounds were hindered from contracting and excessive drying by means of a protective chamber and were allowed to heal by scab formation and granulation.

Functioning hair follicles and sebaceous glands developed in the scars, sometimes in great profusion. It was shown that these structures arose by budding from radially arranged bars of thickened epithelium, at least some of which had grown or migrated from cut hair follicles at the edge of the wound. The dermal papillae formed at about the time of budding of the hair follicles and developed together with them.

The Shope virus induced papillomas on the regenerating skin, but their cell of origin could not be determined.

It is concluded that scar epithelium, under the conditions of the experiments, is capable of redifferentiating into hair follicles and sebaceous glands and that “granulation tissue” of the scar is capable of redifferentiating into dermal papillae.

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This investigation was supported by a research grant (C-1116) from the National Cancer Institute of the National Institutes of Health, Public Health Service.

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