The effects of the Walker 256 carcinoma have been studied in male rats force-fed high fat, carbohydrate, and protein diets until the tumor attained a size of approximately 20 per cent of the body weight.

The loss of nitrogen and fatty acids from the carcasses of tumor-bearing rats was diminished but not prevented by forced feeding.

The total lipid content of the plasma was variable and reached very high values in tumor-bearing rats fed high fat diets. Increases in phospholipid and total cholesterol accounted for only a small fraction of the increase, which is presumably owing to neutral fat.

The nitrogen, total lipid, and phospholipid contents of the livers of tumor-bcarcrs were similar to those of control rats.

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Supported by a grant from the National Cancer Institute of Canada. An abstract has been published in Cancer Research, 12:300, 1952.

The work reported was taken from a thesis submitted by A. G. Stewart for the degree of Doctor of Philosophy at the University of Western Ontario.

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