The influence of varying the salt content of the diet on the genesis and growth of the spontaneous mammary carcinoma and carcinogen-induced skin tumors of the mouse was investigated. The studies utilized partially purified rations containing a standard salt mixture at levels of 2, 4, or 8 per cent of the diet—considered to be the physiological range for dietary minerals. When the experimental conditions were controlled so that the groups of mice were equivalent as to mean caloric intake and body weight, no significant differences were observed in the incidences or mean times of appearance of the neoplasms, or in their rate of growth.


This investigation was supported, in part, by research grant C248 from the National Cancer Institute of the National Institutes of Health, Public Health Service.

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