Some metabolic characteristics of an ascites thymoma in DBA mice, as a function of the number of days after inoculation of the tumor into the host, have been determined. The weight/cell, volume/cell, and cell dry weight/ml of cell suspension rose to a maximum 6–8 days after inoculation and then declined. The amount of PNA/cell and of DNA/cell also showed a cyclic rise and fall. The R.Q., QO2CO2, and QN2CO2, increased with age, the latter reaching values as high as 83. The Qo remained essentially constant during the course of the growth of the tumor. It is suggested that the ascites tumor undergoes a period of rapid proliferation, followed by a decline in growth rate.
This investigation was supported in part by a research grant from the National Cancer Institute of the National Institutes of Health, Public Health Service.