The ascorbic acid levels of normal organs of six strains of mice were compared. The concentration in the spleens of C57 mice and in related strains appeared to be higher than in DBA or C3H mice. The concentration of ascorbic acid in the adrenals of C57BL mice was the highest of the six strains examined. The concentration of ascorbic acid in the kidneys of DBA mice was lower than in the five other strains. The amounts in blood, liver, and brain were similar in all six strains.

Increases of varying degrees were observed in the ascorbic acid concentrations in kidneys and livers of DBA and C3H mice bearing transplants of a mouse bronchogenic carcinoma, the Brown-Pearce rabbit carcinoma, or a human hypernephroma. Adrenals as well as kidneys of C3H mice bearing spontaneous mammary carcinomas possessed significantly increased amounts of ascorbic acid. In C57BL mice, transplants of mammary carcinoma 755 induced decreases in tissue ascorbic acid levels.

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This work was supported by grants from the American Cancer Society, the Jane Coffin Childs Memorial Fund for Medical Research, and the National Cancer Institute, National Institutes of Health, U.S. Public Health Service.

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