An in vitro demonstration of the inhibition of catalase by tumor extracts has been provided. The material also inhibits other iron porphyrin enzymes. It appears to be a relatively stable, low molecular weight compound that functions by combination with the enzyme through the iron porphyrin group. The material has been found in low concentrations in the livers and spleens of normal animals.

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This work was supported in part by a grant from the Wisconsin Alumni Research Foundation.

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©1952 American Association for Cancer Research.
1952
Cancer Research, Inc.