Young, adult, male, albino rats in which Walker carcinoma 256 grew progressively lost more calories than did pair-fed noncancerous rats of the same age and initial weight. The caloric deficit measured by bomb calorimetry equalled the caloric value of the excess lipid lost by the cancerous animals. It was acquired only after the neoplasm had attained a critical mass and increased steadily thereafter.

The estimated expenditure by the host of energy derived from fat and carbohydrate during the period of tumor growth appeared to bear a constant relationship to the weight of the Walker carcinoma.

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This study was aided by a grant from the American Society, on recommendation of the Committee on Growth of the National Research Council.

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