A Study on the Biologic Activity of a Transplanted Granulosa-Cell Tumor in Castrate C57 Mice

A Study on the Biologic Activity of a Transplanted Granulosa-Cell Tumor in Castrate C57 Mice^*

E. S. Crelin;

E. S. Crelin

†Pre-doctorate research fellow, National Institutes of Health.

(From the

Department of Anatomy, Yale University School of Medicine

New Haven 11, Conn.

)

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J. T. Wolstenholme

‡Post-doctorate research fellow, National Institutes of Health.

(From the

Department of Anatomy, Yale University School of Medicine

New Haven 11, Conn.

)

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PubMed

Received: November 17 1950

Online Issn: 1538-7445

Print Issn: 0008-5472

1951

Cancer Research, Inc.

Cancer Res (1951) 11 (3): 212–215.

Summary

A study of a transplanted granulosa-cell tumor in C57 castrate mice revealed a close correlation between the size and weight of the tumor and the quantity of estrogenic substance secreted.
It was estimated that a tumor weighing 4.30 gm. was secreting an amount of estrogenic substance with a stimulating effect approximately equal to that which 0.06 µg. of estradiol benzoate has on the vaginal mucosa of C57 mice.
A close correlation was also found to exist between the size and weight of the tumor and the severity of hypervolemic changes which occurred in the tumor-bearing mice.

This investigation was supported by a research grant from the Public Health Service.

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1951

Cancer Research, Inc.