Data are presented on the levels of intermediates in the glycolytic cycle for two mouse mammary adenocarcinomas, one of which is normally rapidly growing (dbrB) and the other relatively slowly growing (C3H). The pattern of compounds present corresponds to that found in normal differentiated tissues, except that the lactic acid level is considerably higher in these tumors.

The more rapidly growing mammary tumor (dbrB) shows significantly higher levels of glucose-1-phosphate, adenosine triphosphate, and possibly glycogen, and a lower level of inorganic phosphorus than those of the C3H mammary tumor. These findings are in agreement with other studies carried out with this tumor and strongly suggest that a higher level of energy is available for vital function in the dbrB tumor.

The significance of the in vitro and in vivo differences in the lactic acid production of the two mammary tumors is discussed.

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Supported by grants obtained by the senior author (A. G.) from the National Cancer Institute, U.S.P.H.S., and from the Damon Runyon Fund.

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