Liver catalase activity is decreased by the growth of the Jensen sarcoma in protein-depleted rats, but the decrease is not so severe as that achieved in tumor-bearing rats on a normal diet. This may be related to the smaller amount of tumor growth in the former. Protein-depleted rats with tumor show evidence of liver and kidney catalase synthesis in the presence of tumor when supplied with a diet of 100 per cent casein. Normal levels of liver catalase activity with appreciable tumor growth are attained initially but are eventually lowered to levels characteristic of animals bearing rapidly growing Jensen sarcoma. Kidney catalase activity of normal or tumor-bearing rats is elevated by a 100 per cent casein diet above that of rats on a normal protein diet.

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This investigation was aided by a grant from the University of California cancer research fund.

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