Sarcoma 180 was subjected to increased local compression, by implantation into the tail of mice of the Rockland Farms albino strain, with resulting retardation of tumor growth, increase in the frequency of tumor hemorrhage, and increase in the regression rate.

Compression decreased the transplantability of this tumor, under the conditions outlined.

Compression of the tumor-bearing mice, in vivo, resulted in retardation of tumor growth and increased susceptibility to tumor hemorrhage.

These effects seem to have been due to compression itself and not to any variation in the concentration of oxygen.

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This work was supported by a grant made to the Sloan-Kettering Institute for Cancer Research by the American Cancer Society.

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