Few prospective cohort studies have examined the association between fruit and vegetable intake and cancer incidence in Asian population, who consume a diet rich in fruit and vegetable and experience dramatic change in their diet. We investigated whether total fruit intake, total vegetable intake, and total fruit and vegetable intake were associated with risk of incident cancers among 13,563 Korean men during 15 years of follow-up. We used the Cox proportional hazards model to calculate relative risks (RRs) and 95% confidence intervals (CIs) for incident cancers according to fruit and vegetable intake assessed by a validated food frequency-questionnaire. All statistical tests were two-sided. We identified a total of 831 incident cancers. We observed that low intake of total vegetable intake or total fruit and vegetable intake was associated with increased risk of overall cancer incidence. The risk reduction was attributable to increasing intake above a threshold of approximately 100 to 150 g/d. For example, compared with <100 g/d of total fruit and vegetable intake, RRs (95% CIs) for overall cancer risk were 0.74 (0.53-1.02) for 100-<300 g/d, 0.73 (0.53-1.01) for 300-<500 g/d, 0.76 (0.53-1.11) for 500-<600 g/d, and 0.71 (0.51-0.99) for 600 or more g/d. However, when we chose <200 g/d as the referent category, we did not observe the statistically significant associations. In conclusion, our findings suggest that low levels of fruit and vegetable intake could pose an increase in risk of cancer, but the risk could be minimized with modestly increasing intake.

Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 658. doi:1538-7445.AM2012-658