Objective: To evaluate the high-pathogenicity island locus of H. pylori are associated with gastroduodenal disease and gastric cancer.

Method: High-pathogenicity island locus ureA, cagA, vacA of H pylori were detected in biopsy tissues obtained from patients with gastroduodenal disease by polymerase chain reaction.

Results: A total of 135 biopsy samples obtained from patients with gastroduodenal diseases (26 chronic gastritis, 17 atrophic gastritis, 57 peptic ulcer, 35 gastric cancer) were detected by polymerase chain reaction and 85 (63.0%) biopsy samples were high-pathogenicity island locus of H. pylori positive. For 26 chronic gastritis cases the positive rates of high-pathogenicy island locus ureA,cagA and vacA were 53.8%, 46.2%, and 38.5%, respectively. For 17 atrophic gastritis cases they were 64.7%, 52.9% and 41.2%, respectively. For 57 peptic ulcer cases they were 56.2%, 50.9% and 42.2%, respectively. For 35 gastric cancer cases they were 80.0%, 74.3% and 71.4%, respectively. The positive rate of gastric cancer group was the highest one among the four groups and has statistic significance compared with the other three groups respectively (P<0.05). 12 strains of H. pylori were isolated from 19 patients with gastric cancer and the positive rates of locus ureA, cagA, vacA in the 12 strains are 100%, 83.3%, 66.7%, respectively.

Conclusion: High-pathogenicity island locus of H. pylori are important pathogenicity cause for gastric cancer, atrophic gastritis and other gastroduodenal diseases.

98th AACR Annual Meeting-- Apr 14-18, 2007; Los Angeles, CA