An Altered 11-Kilobase Transcript in Leukemic Cell Lines with the t(4;11)(q21;q23) Chromosome Translocation

Cimino, G.; Nakamura, T.; Gu, Y.; Canaani, O.; Prasad, R.; Crist, W. M.; Carroll, A. J.; Baer, M.; Bloomfield, C. D.; Nowell, P. C.; Croce, C. M.; Canaani, E.

Articles| July 01 1992

An Altered 11-Kilobase Transcript in Leukemic Cell Lines with the t(4;11)(q21;q23) Chromosome Translocation^¹

G. Cimino;

G. Cimino

Jefferson Cancer Institute, Jefferson Cancer Center and Department of Microbiology and Immunology, Jefferson Medical College of Thomas Jefferson University

Philadelphia, Pennsylvania 19107 [G. C., T. N., Y. G., O. C., R. P., C. M. C., E. C.]

;

St. Jude Children's Research Hospital, and the University of Tennessee, Memphis College of Medicine

Memphis, Tennessee 38101 [W. M. C.]

;

University of Alabama at Birmingham

Birmingham, Alabama 35294 [A. J. C.]

; the

Pediatric Oncology Group

St. Louis, Missouri 63108 [W. M. C. and A. J. C.]

;

Roswell Park Cancer Institute

Buffalo, New York 14623 [M. B., C. D. B.]

; and

University of Pennsylvania

Philadelphia, Pennsylvania 19104 [P. C. N.]

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T. Nakamura;

T. Nakamura

Jefferson Cancer Institute, Jefferson Cancer Center and Department of Microbiology and Immunology, Jefferson Medical College of Thomas Jefferson University

Philadelphia, Pennsylvania 19107 [G. C., T. N., Y. G., O. C., R. P., C. M. C., E. C.]

;

St. Jude Children's Research Hospital, and the University of Tennessee, Memphis College of Medicine

Memphis, Tennessee 38101 [W. M. C.]

;

University of Alabama at Birmingham

Birmingham, Alabama 35294 [A. J. C.]

; the

Pediatric Oncology Group

St. Louis, Missouri 63108 [W. M. C. and A. J. C.]

;

Roswell Park Cancer Institute

Buffalo, New York 14623 [M. B., C. D. B.]

; and

University of Pennsylvania

Philadelphia, Pennsylvania 19104 [P. C. N.]

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Y. Gu;

Y. Gu

Jefferson Cancer Institute, Jefferson Cancer Center and Department of Microbiology and Immunology, Jefferson Medical College of Thomas Jefferson University

Philadelphia, Pennsylvania 19107 [G. C., T. N., Y. G., O. C., R. P., C. M. C., E. C.]

;

St. Jude Children's Research Hospital, and the University of Tennessee, Memphis College of Medicine

Memphis, Tennessee 38101 [W. M. C.]

;

University of Alabama at Birmingham

Birmingham, Alabama 35294 [A. J. C.]

; the

Pediatric Oncology Group

St. Louis, Missouri 63108 [W. M. C. and A. J. C.]

;

Roswell Park Cancer Institute

Buffalo, New York 14623 [M. B., C. D. B.]

; and

University of Pennsylvania

Philadelphia, Pennsylvania 19104 [P. C. N.]

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O. Canaani;

O. Canaani

Jefferson Cancer Institute, Jefferson Cancer Center and Department of Microbiology and Immunology, Jefferson Medical College of Thomas Jefferson University

Philadelphia, Pennsylvania 19107 [G. C., T. N., Y. G., O. C., R. P., C. M. C., E. C.]

;

St. Jude Children's Research Hospital, and the University of Tennessee, Memphis College of Medicine

Memphis, Tennessee 38101 [W. M. C.]

;

University of Alabama at Birmingham

Birmingham, Alabama 35294 [A. J. C.]

; the

Pediatric Oncology Group

St. Louis, Missouri 63108 [W. M. C. and A. J. C.]

;

Roswell Park Cancer Institute

Buffalo, New York 14623 [M. B., C. D. B.]

; and

University of Pennsylvania

Philadelphia, Pennsylvania 19104 [P. C. N.]

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R. Prasad;

R. Prasad

Jefferson Cancer Institute, Jefferson Cancer Center and Department of Microbiology and Immunology, Jefferson Medical College of Thomas Jefferson University

Philadelphia, Pennsylvania 19107 [G. C., T. N., Y. G., O. C., R. P., C. M. C., E. C.]

;

St. Jude Children's Research Hospital, and the University of Tennessee, Memphis College of Medicine

Memphis, Tennessee 38101 [W. M. C.]

;

University of Alabama at Birmingham

Birmingham, Alabama 35294 [A. J. C.]

; the

Pediatric Oncology Group

St. Louis, Missouri 63108 [W. M. C. and A. J. C.]

;

Roswell Park Cancer Institute

Buffalo, New York 14623 [M. B., C. D. B.]

; and

University of Pennsylvania

Philadelphia, Pennsylvania 19104 [P. C. N.]

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W. M. Crist;

W. M. Crist

Jefferson Cancer Institute, Jefferson Cancer Center and Department of Microbiology and Immunology, Jefferson Medical College of Thomas Jefferson University

Philadelphia, Pennsylvania 19107 [G. C., T. N., Y. G., O. C., R. P., C. M. C., E. C.]

;

St. Jude Children's Research Hospital, and the University of Tennessee, Memphis College of Medicine

Memphis, Tennessee 38101 [W. M. C.]

;

University of Alabama at Birmingham

Birmingham, Alabama 35294 [A. J. C.]

; the

Pediatric Oncology Group

St. Louis, Missouri 63108 [W. M. C. and A. J. C.]

;

Roswell Park Cancer Institute

Buffalo, New York 14623 [M. B., C. D. B.]

; and

University of Pennsylvania

Philadelphia, Pennsylvania 19104 [P. C. N.]

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A. J. Carroll;

A. J. Carroll

Jefferson Cancer Institute, Jefferson Cancer Center and Department of Microbiology and Immunology, Jefferson Medical College of Thomas Jefferson University

Philadelphia, Pennsylvania 19107 [G. C., T. N., Y. G., O. C., R. P., C. M. C., E. C.]

;

St. Jude Children's Research Hospital, and the University of Tennessee, Memphis College of Medicine

Memphis, Tennessee 38101 [W. M. C.]

;

University of Alabama at Birmingham

Birmingham, Alabama 35294 [A. J. C.]

; the

Pediatric Oncology Group

St. Louis, Missouri 63108 [W. M. C. and A. J. C.]

;

Roswell Park Cancer Institute

Buffalo, New York 14623 [M. B., C. D. B.]

; and

University of Pennsylvania

Philadelphia, Pennsylvania 19104 [P. C. N.]

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M. Baer;

M. Baer

Jefferson Cancer Institute, Jefferson Cancer Center and Department of Microbiology and Immunology, Jefferson Medical College of Thomas Jefferson University

Philadelphia, Pennsylvania 19107 [G. C., T. N., Y. G., O. C., R. P., C. M. C., E. C.]

;

St. Jude Children's Research Hospital, and the University of Tennessee, Memphis College of Medicine

Memphis, Tennessee 38101 [W. M. C.]

;

University of Alabama at Birmingham

Birmingham, Alabama 35294 [A. J. C.]

; the

Pediatric Oncology Group

St. Louis, Missouri 63108 [W. M. C. and A. J. C.]

;

Roswell Park Cancer Institute

Buffalo, New York 14623 [M. B., C. D. B.]

; and

University of Pennsylvania

Philadelphia, Pennsylvania 19104 [P. C. N.]

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C. D. Bloomfield;

C. D. Bloomfield

Jefferson Cancer Institute, Jefferson Cancer Center and Department of Microbiology and Immunology, Jefferson Medical College of Thomas Jefferson University

Philadelphia, Pennsylvania 19107 [G. C., T. N., Y. G., O. C., R. P., C. M. C., E. C.]

;

St. Jude Children's Research Hospital, and the University of Tennessee, Memphis College of Medicine

Memphis, Tennessee 38101 [W. M. C.]

;

University of Alabama at Birmingham

Birmingham, Alabama 35294 [A. J. C.]

; the

Pediatric Oncology Group

St. Louis, Missouri 63108 [W. M. C. and A. J. C.]

;

Roswell Park Cancer Institute

Buffalo, New York 14623 [M. B., C. D. B.]

; and

University of Pennsylvania

Philadelphia, Pennsylvania 19104 [P. C. N.]

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P. C. Nowell;

P. C. Nowell

Jefferson Cancer Institute, Jefferson Cancer Center and Department of Microbiology and Immunology, Jefferson Medical College of Thomas Jefferson University

Philadelphia, Pennsylvania 19107 [G. C., T. N., Y. G., O. C., R. P., C. M. C., E. C.]

;

St. Jude Children's Research Hospital, and the University of Tennessee, Memphis College of Medicine

Memphis, Tennessee 38101 [W. M. C.]

;

University of Alabama at Birmingham

Birmingham, Alabama 35294 [A. J. C.]

; the

Pediatric Oncology Group

St. Louis, Missouri 63108 [W. M. C. and A. J. C.]

;

Roswell Park Cancer Institute

Buffalo, New York 14623 [M. B., C. D. B.]

; and

University of Pennsylvania

Philadelphia, Pennsylvania 19104 [P. C. N.]

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C. M. Croce;

C. M. Croce

Jefferson Cancer Institute, Jefferson Cancer Center and Department of Microbiology and Immunology, Jefferson Medical College of Thomas Jefferson University

Philadelphia, Pennsylvania 19107 [G. C., T. N., Y. G., O. C., R. P., C. M. C., E. C.]

;

St. Jude Children's Research Hospital, and the University of Tennessee, Memphis College of Medicine

Memphis, Tennessee 38101 [W. M. C.]

;

University of Alabama at Birmingham

Birmingham, Alabama 35294 [A. J. C.]

; the

Pediatric Oncology Group

St. Louis, Missouri 63108 [W. M. C. and A. J. C.]

;

Roswell Park Cancer Institute

Buffalo, New York 14623 [M. B., C. D. B.]

; and

University of Pennsylvania

Philadelphia, Pennsylvania 19104 [P. C. N.]

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E. Canaani

Jefferson Cancer Institute, Jefferson Cancer Center and Department of Microbiology and Immunology, Jefferson Medical College of Thomas Jefferson University

Philadelphia, Pennsylvania 19107 [G. C., T. N., Y. G., O. C., R. P., C. M. C., E. C.]

;

St. Jude Children's Research Hospital, and the University of Tennessee, Memphis College of Medicine

Memphis, Tennessee 38101 [W. M. C.]

;

University of Alabama at Birmingham

Birmingham, Alabama 35294 [A. J. C.]

; the

Pediatric Oncology Group

St. Louis, Missouri 63108 [W. M. C. and A. J. C.]

;

Roswell Park Cancer Institute

Buffalo, New York 14623 [M. B., C. D. B.]

; and

University of Pennsylvania

Philadelphia, Pennsylvania 19104 [P. C. N.]

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Author & Article Information

To whom requests for reprints should be addressed.

Received: April 28 1992

Accepted: May 26 1992

Online ISSN: 1538-7445

Print ISSN: 0008-5472

1992

Cancer Research, Inc.

Cancer Res (1992) 52 (13): 3811–3813.

Abstract

The 11q23 chromosome band is frequently associated with chromosomal aberrations in human leukemias. We have previously cloned a DNA fragment derived from chromosome 11 which could be used as a probe to detect rearrangements in DNAs from the leukemic cells of patients with the t(4;11), t(9;11), and t(11;19) translocations. In this study we now show that the same probe detects DNA rearrangements in malignant cells from patients with the t(1;11), t(6;11), t(10;11), and del (11q23) chromosomal abnormalities. A second probe obtained from a region located centrometric to the breakpoint cluster detects major and minor transcripts of 12.5 and 11.5 kilobases, respectively, in all cell lines examined. The same probe identifies an altered 11-kilobase RNA in all three independent cell lines with the t(4;11)(q21;q23) chromosome translocation.

Supported by an Outstanding Investigation Grant (CA39860) to C. M. C. from the National Cancer Institute and National Cancer Institute Grants CA30969, CA31566, and CA21765.

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1992

Cancer Research, Inc.

An Altered 11-Kilobase Transcript in Leukemic Cell Lines with the t(4;11)(q21;q23) Chromosome Translocation^¹

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An Altered 11-Kilobase Transcript in Leukemic Cell Lines with the t(4;11)(q21;q23) Chromosome Translocation1

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An Altered 11-Kilobase Transcript in Leukemic Cell Lines with the t(4;11)(q21;q23) Chromosome Translocation^¹