B16/F10 melanoma cells, in a medium containing fibrinogen, form a coating of fibrin(ogen) on their surfaces. This coating is cross-linked in a manner characteristic of catalysis by cellular transglutaminase. The fibrin(ogen) coating on the surface of these tumor cells provides protection against the lytic effect of autologous lymphokine-activated killer cells.


Preliminary results of this work were presented at the Joint Meeting of the American Society for Biochemistry and Molecular Biology and the American Society for Cell Biology, San Francisco, CA, January 29 to February 2, 1989 (Abstract 4713).

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