Wistar rats were given a single intragastric dose of 2–5 mg of 3-methylcholanthrene at age 8–15 days. Five of 16 females and 6 of 10 males developed sarcoma, of which 5 were in the cervical and 4 in the axillary subcutaneous areas, and 1 each in the vaginal and thoracic region. Two of the 11 tumors contained liposarcomatous elements. There were no epithelial neoplasms of the breast, sebaceous glands, or skin, nor leukemias.


This work was supported in part by Grant CA-07771 from the National Cancer Institute, NIH, USPHS.

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