Summary
Disruption of mast cells by the administration of distilled water, polymyxin B, compound 48/80, or tumor polypeptide derived from rat sarcoma produced alterations in I131 distribution similar to those seen in a tumor-bearing animal. Injection of two of the known mast cell components, histamine and 5-HT, also caused this alteration, called iodide trapping. Heparin had no activity in this respect. Reserpine, because of its ability to release 5-HT from the body, produced the trapping syndrome.
These factors, together with the knowledge that growth of the tumor causes a progressive, widespread decrease in the number of intact mast cells, indicate that the release of histamine and/or 5-HT resulting from this disruption of mast cells may be responsible for the iodide trapping observed in the tumor-bearing animal.
This work was supported by a grant from the Henry, Laura, and Irene B. Dernham Fund of the American Cancer Society, California Division, and by Cancer Research Funds of the University of California.
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