Five human cancers are described which are being propagated as transplantable tumors in laboratory animals treated with x-radiation and/or cortisone. Two of these neoplasms, H.S. #1, which has been maintained for over 16 months, and H.Ep. #3, which has been in culture for a shorter period, are now being produced in such quantity that over 800 animals per week are needed for transfer of the two growths; a steady supply of tumor-bearing animals and of tumor material is available also for investigators. Both tumors are growing well on the membrane of the chick egg and in tissue culture.

Because a single subcutaneous dose of cortisone injected at the time of tumor implantation is sufficient to insure the growth of H.S. #1 or H.Ep. #3 in the pouches of nonirradiated hamsters, these animals are considered ideal for research purposes. It is felt that such a small dose is not likely to interfere with experimental work on tumors 7–14 days old.

None of the human tumors has ever grown in normal, untreated control hosts.


This investigation has been aided by a grant from The Jane Coffin Childs Memorial Fund for Medical Research, the National Cancer Institute of the U.S. Public Health Service, the American Cancer Society, and the Damon Runyon Memorial Fund for Cancer Research.

Approximately one-third of the cortisone acetate (Cortone, Merck) used for these experiments has been supplied through the courtesy of Merck & Co., Inc., Rahway, N.J.

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