Studies on the Effects of a Guanine Analog on Acute Lymphoid Leukemias of Mice

Studies on the Effects of a Guanine Analog on Acute Lymphoid Leukemias of Mice^*

L. W. Law, Ph.D.

(From the

National Cancer Institute, National Institutes of Health, United States Public Health Service

Bethesda, Maryland

)

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Received: December 02 1949

Online ISSN: 1538-7445

Print ISSN: 0008-5472

1950

Cancer Research, Inc.

Cancer Res (1950) 10 (3): 186–190.

Summary

A definite, regular, and reproducible inhibition of two transplantable acute lymphoid leukemias in mice resulted from parenteral administration of the guanine analog, guanazolo.
No effect of this compound on a transplantable lymphosarcoma was observed.
Apparent release of inhibition by the use of guanine HCl is recorded.

The technical assistance of Mr. Peter Boyle and Mr. J. H. Miller is gratefully acknowledged.

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1950

Cancer Research, Inc.