Immunotherapy of cancer is a burgeoning field of research since the realization that our immune system intrinsically has the capacity to restrict tumor occurrence and progression. Though strategies to maximize antitumor T-cell activation are well established, the efficacy of these therapies is limited by an insufficient knowledge of the intricate tumor microenvironment and its capacity to thwart antitumor immunity. Chen and colleagues now uncover a novel immunosuppressive pathway in non–small cell lung carcinoma. Overexpression of cytochrome P450F2 in cancer cells increases production of 20-hydroxyeicosatetraenoic acid, which instructs the expression of immunosuppressive molecules in cancer-associated fibroblasts by binding the GPR75 receptor and activating STAT3/c-Jun signaling. This work proposes several innovative therapeutic anchor points that may improve the efficacy of existing immunotherapies.
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1 November 2022
Cancer Research Highlights|
November 02 2022
The Heat Is On: 20-HETE Instructs an Immunosuppressive Phenotype in Cancer-Associated Fibroblasts
Jo A. Van Ginderachter
Jo A. Van Ginderachter
*
1Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium.
2Myeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium.
*Corresponding Author: Jo A. Van Ginderachter, Laboratory of Cellular and Molecular Immunology, Myeloid Cell Immunology Lab, VIB-Vrije Universiteit Brussel, Vrije Universiteit Brussel, Building E, Level 8, Pleinlaan 2, Brussels B-1050, Belgium. E-mail: [email protected]
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*Corresponding Author: Jo A. Van Ginderachter, Laboratory of Cellular and Molecular Immunology, Myeloid Cell Immunology Lab, VIB-Vrije Universiteit Brussel, Vrije Universiteit Brussel, Building E, Level 8, Pleinlaan 2, Brussels B-1050, Belgium. E-mail: [email protected]
Cancer Res 2022;82:3882–3
Received:
August 31 2022
Accepted:
September 01 2022
Online ISSN: 1538-7445
Print ISSN: 0008-5472
©2022 American Association for Cancer Research
2022
American Association for Cancer Research
Cancer Res (2022) 82 (21): 3882–3883.
Article history
Received:
August 31 2022
Accepted:
September 01 2022
Related Content
A commentary has been published:
CYP4F2-Catalyzed Metabolism of Arachidonic Acid Promotes Stromal Cell-Mediated Immunosuppression in Non–Small Cell Lung Cancer
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Citation
Jo A. Van Ginderachter; The Heat Is On: 20-HETE Instructs an Immunosuppressive Phenotype in Cancer-Associated Fibroblasts. Cancer Res 1 November 2022; 82 (21): 3882–3883. https://doi.org/10.1158/0008-5472.CAN-22-2774
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