Abstract
In this issue of Cancer Research, Liang and colleagues perform a genome-wide CRISPR-Cas9–negative loss-of-function screen and identify WEE1 kinase as a therapeutic vulnerability in cells depleted of the ATRX chromatin remodeler gene. Because ATRX mutations are frequently mutated across a variety of pediatric and adult malignancies, this work may contribute to the preclinical rationale for a precision medicine trial of the WEE1 inhibitor AZD1775 (adavosertib) for patients whose tumors demonstrate ATRX loss.
See related article by Liang et al., p. 510
©2020 American Association for Cancer Research.
2020
American Association for Cancer Research.
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