The purpose of scientific journals, including that of Cancer Research, is to convey peer-reviewed information gleaned from rigorously executed experiments to answer specific questions and to test hypotheses that advance the field. Cancer biology is inherently complex with the interplay between cancer cell–intrinsic alterations that juxtapose with the tumor microenvironment, which provides the host's ability to control or give in to the progression of neoplastic lesions. Cancer cell–intrinsic alterations stemming from genetic or epigenetic alterations of oncogenic drivers contribute to the aberrant neoplastic cell that has lost normal feedback loops to attenuate cell growth and proliferation in the absence of external cues, including growth factors, extracellular matrix mechanical cues, and nutrient availability. The host's stromal and immune cells react to emerging neoplastic lesions as if they are infected by microorganisms and attempt to control cancer progression through inflammatory signals, which can be hijacked by cancer cells to favor immune...

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