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Powel H. Brown
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Journal Articles

Preventive Treatment with a CD73 Small Molecule Inhibitor Enhances Immune Surveillance in K-Ras Mutant Pancreatic Intraepithelial Neoplasia

Open Access
Lincoln N. Strickland, Wendao Liu, Usama Hussein, Nicolette Mardik, Xian Chen, Tingting Mills, Lana A. Vornik, Michelle I. Savage, Shizuko Sei, John Clifford, Holger K. Eltzschig, Powel H. Brown, Zhongming Zhao, Florencia McAllister, Jennifer M. Bailey-Lundberg
Journal: Cancer Prevention Research
Cancer Prev Res (Phila) (2024) 17 (10): 457–470.
https://doi.org/10.1158/1940-6207.CAPR-24-0200
Published: 01 October 2024
View articletitled, Preventive Treatment with a CD73 Small Molecule Inhibitor Enhances Immune Surveillance in K-Ras Mutant Pancreatic Intraepithelial Neoplasia
Open the PDF for Preventive Treatment with a CD73 Small Molecule Inhibitor Enhances Immune Surveillance in K-Ras Mutant Pancreatic Intraepithelial Neoplasia in another window
Includes: Supplementary data
Journal Articles

Phase II Trial of Nelipepimut-S Peptide Vaccine in Women with Ductal Carcinoma In Situ

Available to Purchase
Anne E. O'Shea, Guy T. Clifton, Na Qiao, Brandy M. Heckman-Stoddard, Malgorzata Wojtowicz, Eileen Dimond, Isabelle Bedrosian, Diane Weber, Judy E. Garber, Alexander Husband, Ricardo Pastorello, J. Jack Lee, Mike Hernandez, Diane D. Liu, Lana A. Vornik, Powel H. Brown, Gheath Alatrash, George E. Peoples, Elizabeth A. Mittendorf
Journal: Cancer Prevention Research
Cancer Prev Res (Phila) (2023) 16 (6): 333–341.
https://doi.org/10.1158/1940-6207.CAPR-22-0388
Published: 01 June 2023
View articletitled, Phase II Trial of Nelipepimut-S Peptide Vaccine in Women with Ductal Carcinoma In Situ
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Includes: Supplementary data
Journal Articles

Phase I Dose Escalation Study of Topical Bexarotene in Women at High Risk for Breast Cancer

Available to Purchase
Parijatham S. Thomas, Anisha B. Patel, J. Jack Lee, Diane D. Liu, Mike Hernandez, Miguel Muzzio, Alejandro Contreras, Valerie Sepeda, Carrie Mays, Diane Weber, Lana A. Vornik, Seema A. Khan, Eileen Dimond, Brandy M. Heckman-Stoddard, Marjorie Perloff, Powel H. Brown
Journal: Cancer Prevention Research
Cancer Prev Res (Phila) (2023) 16 (1): 47–55.
https://doi.org/10.1158/1940-6207.CAPR-22-0210
Published: 04 January 2023
View articletitled, Phase I Dose Escalation Study of Topical Bexarotene in Women at High Risk for Breast Cancer
Open the PDF for Phase I Dose Escalation Study of Topical Bexarotene in Women at High Risk for Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Treatment Strategies and Mechanisms Associated with the Prevention of NASH-Associated HCC by a Toll-like Receptor 4 Inhibitor

Available to Purchase
Suet-Ying Kwan, Alyssa N. Slayden, Aubrey R. Coronado, Rosamaria C. Marquez, Huiqin Chen, Peng Wei, Michelle I. Savage, Lana A. Vornik, Jennifer T. Fox, Shizuko Sei, Dong Liang, Heather L. Stevenson, Gregory K. Wilkerson, Mihai Gagea, Powel H. Brown, Laura Beretta
Journal: Cancer Prevention Research
Cancer Prev Res (Phila) (2023) 16 (1): 17–28.
https://doi.org/10.1158/1940-6207.CAPR-22-0332
Published: 04 January 2023
View articletitled, Treatment Strategies and Mechanisms Associated with the Prevention of NASH-Associated HCC by a Toll-like Receptor 4 Inhibitor
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Includes: Supplementary data
Journal Articles

Abstract IA017: Targeting the mTOR pathway for the prevention of triple-negative breast cancer

Free
Powel H. Brown, Abhijit Mazumdar, William Tahaney, Jamal Hill, Yun Zhang, Sumankalai Ramachandran, Jitesh Kawedia, Jing Qian, Alejandra Contreras, Michelle Savage, Lana Vornik
Journal: Cancer Prevention Research
Cancer Prev Res (Phila) (2023) 16 (1_Supplement): IA017.
https://doi.org/10.1158/1940-6215.PrecPrev22-IA017
Published: 01 January 2023
View articletitled, Abstract IA017: Targeting the mTOR pathway for the prevention of triple-negative breast cancer
Journal Articles

Abstract IA013: Preclinical testing of CD73 inhibitors for pancreatic cancer immunoprevention

Free
Lincoln Ballew, Kanchan Singh, Vidhi Chandra, Tingting Mills, Erika Y. Faraoni, Victoria Mota, Trent Clark, Lana Vornik, Michelle I. Savage, Shizuko Sei, Altaf Mohammed, Holger K. Eltzschig, Powel H. Brown, Florencia McAllister, Jennifer M. Bailey-Lundberg
Journal: Cancer Prevention Research
Cancer Prev Res (Phila) (2022) 15 (12_Supplement_2): IA013.
https://doi.org/10.1158/1940-6215.TACPAD22-IA013
Published: 01 December 2022
View articletitled, Abstract IA013: Preclinical testing of CD73 inhibitors for pancreatic cancer immunoprevention
Journal Articles

Targeting the mTOR Pathway for the Prevention of ER-Negative Breast Cancer

Open Access
Abhijit Mazumdar, William M. Tahaney, Jamal L. Hill, Yun Zhang, Sumankalai Ramachandran, Jitesh Kawedia, Jing Qian, Alejandro Contreras, Michelle I. Savage, Lana A. Vornik, Shizuko Sei, Altaf Mohammed, Powel H. Brown
Journal: Cancer Prevention Research
Cancer Prev Res (Phila) (2022) 15 (12): 791–802.
https://doi.org/10.1158/1940-6207.CAPR-22-0106
Published: 01 December 2022
View articletitled, Targeting the mTOR Pathway for the Prevention of ER-Negative Breast Cancer
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Includes: Supplementary data
Journal Articles

Abstract A012: Repurposing of the macrolide antibiotic clarithromycin for the prevention of lung cancer

Free
Seyed Javad Moghaddam, Tabish Hussain, Melody Zarghooni, Walter V. Velasco, Linda Phan, Michelle I. Savage, Jennifer T. Fox, Shizuko Sei, Powel H. Brown, C. Marcelo Aldaz
Journal: Cancer Prevention Research
Cancer Prev Res (Phila) (2022) 15 (12_Supplement_2): A012.
https://doi.org/10.1158/1940-6215.TACPAD22-A012
Published: 01 December 2022
View articletitled, Abstract A012: Repurposing of the macrolide antibiotic clarithromycin for the prevention of lung cancer
Journal Articles

Lessons from the Failure to Complete a Trial of Denosumab in Women With a Pathogenic BRCA1/2 Variant Scheduling Risk-Reducing Salpingo-Oophorectomy

Available to Purchase
Meghna S. Trivedi, Nadir Arber, Eitan Friedman, Judy E. Garber, Kevin Holcomb, Neil S. Horowitz, Jason D. Wright, J. Jack Lee, Lana A. Vornik, Saba Abutaseh, Tawana Castile, Edward R. Sauter, Eileen Dimond, Brandy M. Heckman-Stoddard, Margaret House, Goli Samimi, Powel H. Brown, Katherine D. Crew
Journal: Cancer Prevention Research
Cancer Prev Res (Phila) (2022) 15 (11): 721–726.
https://doi.org/10.1158/1940-6207.CAPR-22-0051
Published: 01 November 2022
View articletitled, Lessons from the Failure to Complete a Trial of Denosumab in Women With a Pathogenic BRCA1/2 Variant Scheduling Risk-Reducing Salpingo-Oophorectomy
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Journal Articles

Optimization of Erlotinib Plus Sulindac Dosing Regimens for Intestinal Cancer Prevention in an Apc-Mutant Model of Familial Adenomatous Polyposis (FAP)

Available to Purchase
Ahmet M. Ulusan, Praveen Rajendran, Wan Mohaiza Dashwood, Omer F. Yavuz, Sabeeta Kapoor, Trace A. Gustafson, Michelle I. Savage, Powel H. Brown, Shizuko Sei, Altaf Mohammed, Eduardo Vilar, Roderick H. Dashwood
Journal: Cancer Prevention Research
Cancer Prev Res (Phila) (2021) 14 (3): 325–336.
https://doi.org/10.1158/1940-6207.CAPR-20-0262
Published: 02 March 2021
View articletitled, Optimization of Erlotinib Plus Sulindac Dosing Regimens for Intestinal Cancer Prevention in an Apc-Mutant Model of Familial Adenomatous Polyposis (FAP)
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Includes: Supplementary data
Journal Articles

Randomized Double-Blind Placebo-Controlled Biomarker Modulation Study of Vitamin D Supplementation in Premenopausal Women at High Risk for Breast Cancer (SWOG S0812)

Free
Katherine D. Crew, Garnet L. Anderson, Dawn L. Hershman, Mary Beth Terry, Parisa Tehranifar, Danika L. Lew, Monica Yee, Eric A. Brown, Sebastien S. Kairouz, Nafisa Kuwajerwala, Therese Bevers, John E. Doster, Corrine Zarwan, Laura Kruper, Lori M. Minasian, Leslie Ford, Banu Arun, Marian Neuhouser, Gary E. Goodman, Powel H. Brown
Journal: Cancer Prevention Research
Cancer Prev Res (Phila) (2019) 12 (7): 481–490.
https://doi.org/10.1158/1940-6207.CAPR-18-0444
Published: 03 July 2019
View articletitled, Randomized Double-Blind Placebo-Controlled Biomarker Modulation Study of Vitamin D Supplementation in Premenopausal Women at High Risk for Breast Cancer (SWOG S0812)
Open the PDF for Randomized Double-Blind Placebo-Controlled Biomarker Modulation Study of Vitamin D Supplementation in Premenopausal Women at High Risk for Breast Cancer (SWOG S0812) in another window
Includes: Supplementary data
Journal Articles

A Randomized Multicenter Phase II Study of Docosahexaenoic Acid in Patients with a History of Breast Cancer, Premalignant Lesions, or Benign Breast Disease

Free
Ayca Gucalp, Xi K. Zhou, Elise D. Cook, Judy E. Garber, Katherine D. Crew, Julie R. Nangia, Priya Bhardwaj, Dilip D. Giri, Olivier Elemento, Akanksha Verma, Hanhan Wang, J. Jack Lee, Lana A. Vornik, Carrie Mays, Diane Weber, Valerie Sepeda, Holly O'Kane, Margaret Krasne, Samantha Williams, Patrick G. Morris, Brandy M. Heckman-Stoddard, Barbara K. Dunn, Clifford A. Hudis, Powel H. Brown, Andrew J. Dannenberg
Journal: Cancer Prevention Research
Cancer Prev Res (Phila) (2018) 11 (4): 203–214.
https://doi.org/10.1158/1940-6207.CAPR-17-0354
Published: 01 April 2018
View articletitled, A Randomized Multicenter Phase II Study of Docosahexaenoic Acid in Patients with a History of Breast Cancer, Premalignant Lesions, or Benign Breast Disease
Open the PDF for A Randomized Multicenter Phase II Study of Docosahexaenoic Acid in Patients with a History of Breast Cancer, Premalignant Lesions, or Benign Breast Disease in another window
Includes: Supplementary data
Journal Articles

Phase Ib Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Patients with Barrett's Esophagus

Free
Andrew K. Joe, Felice Schnoll-Sussman, Robert S. Bresalier, Julian A. Abrams, Hanina Hibshoosh, Ken Cheung, Richard A. Friedman, Chung S. Yang, Ginger L. Milne, Diane D. Liu, J. Jack Lee, Kazeem Abdul, Michelle Bigg, Jessica Foreman, Tao Su, Xiaomei Wang, Aqeel Ahmed, Alfred I. Neugut, Esther Akpa, Scott M. Lippman, Marjorie Perloff, Powel H. Brown, Charles J. Lightdale
Journal: Cancer Prevention Research
Cancer Prev Res (Phila) (2015) 8 (12): 1131–1137.
https://doi.org/10.1158/1940-6207.CAPR-14-0274-T
Published: 03 December 2015
View articletitled, Phase Ib Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Patients with Barrett's Esophagus
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Journal Articles

Abstract PR03: Targeting multiple cell cycle regulatory points for the prevention of triple-negative breast cancer

Free
Beate Christiane Litzenburger, Ivan Peter Uray, Jamal Hill, Jun Zhang, Abhijit Mazumdar, Powel H. Brown
Journal: Cancer Prevention Research
Cancer Prev Res (Phila) (2015) 8 (10_Supplement): PR03.
https://doi.org/10.1158/1940-6215.PREV-14-PR03
Published: 02 October 2015
View articletitled, Abstract PR03: Targeting multiple cell cycle regulatory points for the prevention of triple-negative breast cancer
Journal Articles

Abstract PR-10: Randomized placebo controlled trial of pioglitazone for oral premalignant lesions: A cross-consortium collaborative study in progress

Free
Jay O. Boyle, Frank G. Ondrey, Powel H. Brown, Howard H. Bailey, Kyung Mann Kim, Adel K. El-Naggar, Eva M. Szabo
Journal: Cancer Prevention Research
Cancer Prev Res (Phila) (2010) 3 (12_Supplement): PR-10.
https://doi.org/10.1158/1940-6207.PREV-10-PR-10
Published: 24 October 2014
View articletitled, Abstract PR-10: Randomized placebo controlled trial of pioglitazone for oral premalignant lesions: A cross-consortium collaborative study in progress
Journal Articles

Abstract A73: Randomized placebo-controlled trial of pioglitazone for oral premalignant lesions: A cross-consortium collaborative study in progress

Free
Jay O. Boyle, Frank G. Ondrey, Powel H. Brown, Howard H. Bailey, KyungMann Kim, Adel K. El-Naggar, Eva M. Szabo
Journal: Cancer Prevention Research
Cancer Prev Res (Phila) (2010) 3 (12_Supplement): A73.
https://doi.org/10.1158/1940-6207.PREV-10-A73
Published: 24 October 2014
View articletitled, Abstract A73: Randomized placebo-controlled trial of pioglitazone for oral premalignant lesions: A cross-consortium collaborative study in progress
Journal Articles

Abstract B69: Cellular neutral lipid content is a novel biomarker of cancer preventive activity

Free
Ivan P. Uray, Reid Bissonnette, Powel H. Brown
Journal: Cancer Prevention Research
Cancer Prev Res (Phila) (2011) 4 (10_Supplement): B69.
https://doi.org/10.1158/1940-6207.PREV-11-B69
Published: 23 October 2014
View articletitled, Abstract B69: Cellular neutral lipid content is a novel biomarker of cancer preventive activity
Journal Articles

Abstract A45: Targeting breast cancer stem cells using cancer preventive rexinoids

Free
Jing Zhao, Yun Zhang, Jamal L. Hill, Abhijit Mazumdar, Powel H. Brown
Journal: Cancer Prevention Research
Cancer Prev Res (Phila) (2011) 4 (10_Supplement): A45.
https://doi.org/10.1158/1940-6207.PREV-11-A45
Published: 23 October 2014
View articletitled, Abstract A45: Targeting breast cancer stem cells using cancer preventive rexinoids
Journal Articles

Abstract A42: Autocrine-produced IL-6 and IL-8 are essential for the growth and maintenance of the transformed phenotype of basal-like breast cancer cells

Free
Zachary C. Hartman, Anna Tsimelzon, Jamal Hill, Yun Zhang, Abhijit Mazumdar, Susan G. Hilsenbeck, Gordon Mills, Powel H. Brown
Journal: Cancer Prevention Research
Cancer Prev Res (Phila) (2011) 4 (10_Supplement): A42.
https://doi.org/10.1158/1940-6207.PREV-11-A42
Published: 23 October 2014
View articletitled, Abstract A42: Autocrine-produced IL-6 and IL-8 are essential for the growth and maintenance of the transformed phenotype of basal-like breast cancer cells
Journal Articles

Abstract A32: Identification of biomarkers in normal human breast cells regulated by the cancer preventive rexinoid LG100268

Free
Jennifer M. Rodenberg, Ivan P. Uray, Hee‐Tae Kim, Julie Ann Mayer, Reid P. Bissonnette, Powel H. Brown
Journal: Cancer Prevention Research
Cancer Prev Res (Phila) (2010) 3 (1_Supplement): A32.
https://doi.org/10.1158/1940-6207.PREV-09-A32
Published: 21 October 2014
View articletitled, Abstract A32: Identification of biomarkers in normal human breast cells regulated by the cancer preventive rexinoid LG100268