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1 June 2015
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Cover Image
Cover Image
Chronic inflammation induces histopathologic progression of the stomach epithelium leading to the development of metaplasia followed by gastric adenocarcinoma. Inflammation of the gastric epithelium, which produces high levels of reactive oxygen species (ROS), results in a gradual loss of parietal cells and their replacement with proliferative metaplastic cells, suggesting that the inflammation-associated ROS plays a role in the disruption of homeostasis of the gastric epithelium. However, the role of ROS and its downstream signaling in gastric carcinogenesis has remained unknown. The cover illustration depicts the phosphorylated (activated) form of p38MAPK (green) as well as parietal cells (H+,K+-ATPase; red) in normal stomach tissue exposed to the hydrogen peroxide in vitro (nuclei are counterstained in blue). As shown in the yellow signal (red and green overlay), the oxidative stress–dependent activation of p38MAPK is triggered selectively in parietal cells. For more information on the potential mechanisms underlying the oxidative stress–dependent parietal cells loss and consequent gastric carcinogenesis, see the article by Seishima et al. (beginning on page 492). - PDF Icon PDF LinkTable of Contents
ISSN 1940-6207
EISSN 1940-6215
Issue Sections
Research Articles
Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans
Elena V. Knatko; Sally H. Ibbotson; Ying Zhang; Maureen Higgins; Jed W. Fahey; Paul Talalay; Robert S. Dawe; James Ferguson; Jeffrey T.-J. Huang; Rosemary Clarke; Suqing Zheng; Akira Saito; Sukirti Kalra; Andrea L. Benedict; Tadashi Honda; Charlotte M. Proby; Albena T. Dinkova-Kostova
Author Choice
Ink4a/Arf-Dependent Loss of Parietal Cells Induced by Oxidative Stress Promotes CD44-Dependent Gastric Tumorigenesis
Ryo Seishima; Takeyuki Wada; Kenji Tsuchihashi; Shogo Okazaki; Momoko Yoshikawa; Hiroko Oshima; Masanobu Oshima; Toshiro Sato; Hirotoshi Hasegawa; Yuko Kitagawa; James R. Goldenring; Hideyuki Saya; Osamu Nagano
High-Density Lipoprotein-Cholesterol, Daily Estradiol and Progesterone, and Mammographic Density Phenotypes in Premenopausal Women
Vidar G. Flote; Hanne Frydenberg; Giske Ursin; Anita Iversen; Morten W. Fagerland; Peter T. Ellison; Erik A. Wist; Thore Egeland; Tom Wilsgaard; Anne McTiernan; Anne-Sofie Furberg; Inger Thune
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