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1 August 2014
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Cover Image
Cover Image
Oxidative stress accelerates the pathogenesis of a number of chronic diseases, including cancer growth and its metastasis. Transcription factorNrf2 (NF-E2–related factor-2) regulates the cellular defense system against oxidative stress. Systemic deletion of Nrf2 brings about an increased susceptibility to cancer metastasis, which is associated with aberrant ROS (reactive oxygen species) accumulation inmyeloid-derived suppressor cells (MDSCs). However, it remains elusive whether cellular antioxidant defense system regulated by Nrf2 signaling in the myeloid lineage cells plays indispensable roles for metastatic cancer progression. In this study, myeloid lineage–specific Nrf2-deficient (N-MKO) mice are inoculated with mouse Lewis lung carcinoma cells and metastatic activity of the cells is examined. The cover micrograph depicts metastatic cancerous lesions in the lung tissue of tumor-bearing N-MKO mouse. Note that N-MKO mice develop multiple metastatic lung nodules, indicating that the Nrf2-deficiency in myeloid lineage cells accelerates cancer cell metastasis. See the article by Hiramoto and colleagues (beginning on page 835) for more information.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1940-6207
EISSN 1940-6215
Issue Sections
Perspectives
Research Articles
Comparative Effects of Two Different Forms of Selenium on Oxidative Stress Biomarkers in Healthy Men: A Randomized Clinical Trial
John P. Richie, Jr; Arun Das; Ana M. Calcagnotto; Raghu Sinha; Wanda Neidig; Jiangang Liao; Eugene J. Lengerich; Arthur Berg; Terryl J. Hartman; Amy Ciccarella; Aaron Baker; Matthew G. Kaag; Susan Goodin; Robert S. DiPaola; Karam El-Bayoumy
Inactivating Mutation in the Prostaglandin Transporter Gene, SLCO2A1, Associated with Familial Digital Clubbing, Colon Neoplasia, and NSAID Resistance
Kishore Guda; Stephen P. Fink; Ginger L. Milne; Neil Molyneaux; Lakshmeswari Ravi; Susan M. Lewis; Andrew J. Dannenberg; Courtney G. Montgomery; Shulin Zhang; Joseph Willis; Georgia L. Wiesner; Sanford D. Markowitz
Author Choice
Rapid and Sustainable Detoxication of Airborne Pollutants by Broccoli Sprout Beverage: Results of a Randomized Clinical Trial in China
Patricia A. Egner; Jian-Guo Chen; Adam T. Zarth; Derek K. Ng; Jin-Bing Wang; Kevin H. Kensler; Lisa P. Jacobson; Alvaro Muñoz; Jamie L. Johnson; John D. Groopman; Jed W. Fahey; Paul Talalay; Jian Zhu; Tao-Yang Chen; Geng-Sun Qian; Steven G. Carmella; Stephen S. Hecht; Thomas W. Kensler
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