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1 January 2014
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Cover Image
In 2007, the International Agency for Cancer Research presented compelling evidence that linked smokeless tobacco use to the development of human oral cancer. While these findings imply vigorous local carcinogen metabolism, little is known regarding levels and distribution of Phase I, II, and drug egress enzymes in human oral mucosa. The current study integrated clinical data, imaging studies, and histopathologic analyses of an oral squamous cell carcinoma that arose at the site of smokeless tobacco quid placement. The cover depicts a three-dimensional iCAT image of the buccal aspect of the patients leftmandibular body. Themarked bone destruction associated with tobacco quid placement in the buccal vestibule adjacent to the patient's second and first mandibular molars is readily apparent. Immunoblot and immunohistochemical (IHC) analyses were employed to identify tumor and normal human oral mucosal smokeless tobacco-associated metabolic bioactivation and detoxification enzymes. Human oral epithelium contains every known Phase I enzyme capable of nitrosamine oxidative bioactivation with ∼2 fold interdonor differences in protein levels. IHC studies confirmed that oral mucosal nitrosamine metabolizing enzymes reside in the basilar and suprabasilar regions, sites of ongoing keratinocyte DNA replication. Clearly, variations in product composition, capacity for nitrosamine oxidative metabolism and exposure duration will modulate clinical outcomes. The data presented here form a coherent picture consistent with the abundant experimental data that link tobacco-specific nitrosamines to human oral cancer. See article by Mallery and colleagues (beginning on page 23) for more information. - PDF Icon PDF LinkTable of Contents
ISSN 1940-6207
EISSN 1940-6215
Issue Sections
Historical Perspective
Commentary
Research Articles
Nutrition and Physical Activity Cancer Prevention Guidelines, Cancer Risk, and Mortality in the Women's Health Initiative
Cynthia A. Thomson; Marjorie L. McCullough; Betsy C. Wertheim; Rowan T. Chlebowski; Maria Elena Martinez; Marcia L. Stefanick; Thomas E. Rohan; JoAnn E. Manson; Hilary A. Tindle; Judith Ockene; Mara Z. Vitolins; Jean Wactawski-Wende; Gloria E. Sarto; Dorothy S. Lane; Marian L. Neuhouser
A Derivative of Chrysin Suppresses Two-Stage Skin Carcinogenesis by Inhibiting Mitogen- and Stress-Activated Kinase 1
Haidan Liu; Joonsung Hwang; Wei Li; Tae Woong Choi; Kangdong Liu; Zunnan Huang; Jae-Hyuk Jang; N.R. Thimmegowda; Ki Won Lee; In-Ja Ryoo; Jong-Seog Ahn; Ann M. Bode; Xinmin Zhou; Yifeng Yang; Raymond L. Erikson; Bo-Yeon Kim; Zigang Dong
Kava Blocks 4-(Methylnitrosamino)-1-(3-pyridyl)-1-Butanone–Induced Lung Tumorigenesis in Association with Reducing O6-methylguanine DNA Adduct in A/J Mice
Pablo Leitzman; Sreekanth C. Narayanapillai; Silvia Balbo; Bo Zhou; Pramod Upadhyaya; Ahmad Ali Shaik; M. Gerard O'Sullivan; Stephen S. Hecht; Junxuan Lu; Chengguo Xing
Effect of a Low-Fat Fish Oil Diet on Proinflammatory Eicosanoids and Cell-Cycle Progression Score in Men Undergoing Radical Prostatectomy
Colette Galet; Kiran Gollapudi; Sevan Stepanian; Joshua B. Byrd; Susanne M. Henning; Tristan Grogan; David Elashoff; David Heber; Jonathan Said; Pinchas Cohen; William J. Aronson
Dynamic Tumor Growth Patterns in a Novel Murine Model of Colorectal Cancer
Terrah J. Paul Olson; Jamie N. Hadac; Chelsie K. Sievers; Alyssa A. Leystra; Dustin A. Deming; Christopher D. Zahm; Dawn M. Albrecht; Alice Nomura; Laura A. Nettekoven; Lauren K. Plesh; Linda Clipson; Ruth Sullivan; Michael A. Newton; William R. Schelman; Richard B. Halberg
Author Choice
Temporal and Spatial Evolution of Somatic Chromosomal Alterations: A Case-Cohort Study of Barrett's Esophagus
Xiaohong Li; Patricia C. Galipeau; Thomas G. Paulson; Carissa A. Sanchez; Jessica Arnaudo; Karen Liu; Cassandra L. Sather; Rumen L. Kostadinov; Robert D. Odze; Mary K. Kuhner; Carlo C. Maley; Steven G. Self; Thomas L. Vaughan; Patricia L. Blount; Brian J. Reid
Folate Deficiency Induces Dysfunctional Long and Short Telomeres; Both States Are Associated with Hypomethylation and DNA Damage in Human WIL2-NS Cells
Caroline F. Bull; Graham Mayrhofer; Nathan J. O'Callaghan; Amy Y. Au; Hilda A. Pickett; Grace Kah Mun Low; Dimphy Zeegers; M. Prakash Hande; Michael F. Fenech
Cognitive Factors Associated with Adherence to Oral Antiestrogen Therapy: Results from the Cognition in the Study of Tamoxifen and Raloxifene (Co-STAR) Study
Heidi D. Klepin; Ann M. Geiger; Hanna Bandos; Joseph P. Costantino; Stephen R. Rapp; Kaycee M. Sink; Julia A. Lawrence; Hal H. Atkinson; Mark A. Espeland
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