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1 December 2012
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Cover Image
Colorectal cancer is the second leading cause of cancerrelated deaths in the United States. Although noninvasive fecal blood tests are widely used for the early detection of colorectal neoplasia, these tests have limited sensitivity and specificity. Metabolomics can be used to identify and quantify small molecules. In this study, metabolic profiling of feces was evaluated as a potential noninvasive approach to identify biomarkers of colorectal carcinogenesis. The cover image shows time-dependent effect size differences in metabolite levels in feces from colon tumor-bearing mice vs. healthy mice. Feces were analyzed three, five, and seven weeks following six weekly injections of azoxymethane, a colon carcinogen, or saline. The levels of fecal metabolites progressively change as tumor burden increases. Metabolomic profiling of feces represents a promising method to noninvasively detect colorectal tumors. See article by Montrose et al. (beginning on page 1358) for more information.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1940-6207
EISSN 1940-6215
Issue Sections
Perspectives
Review
Research Articles
Benign Breast Disease and the Risk of Subsequent Breast Cancer in African American Women
Michele L. Cote; Julie J. Ruterbusch; Barra Alosh; Sudeshna Bandyopadhyay; Elizabeth Kim; Bassam Albashiti; Aldeen Bashar Sharaf; Derek C. Radisky; Marlene H. Frost; Daniel W. Visscher; Lynn C. Hartmann; Warzecha Hind Nassar; Rouba Ali-Femhi
Design and Baseline Characteristics of Participants in a Phase III Randomized Trial of Celecoxib and Selenium for Colorectal Adenoma Prevention
Patricia Thompson; Denise J. Roe; Liane Fales; Julie Buckmeier; Fang Wang; Stanley R. Hamilton; Achyut Bhattacharyya; Sylvan Green; Chiu-Hsieh Hsu; H.-H. Sherry Chow; Dennis J. Ahnen; C. Richard Boland; Russell I. Heigh; David E. Fay; Maria Elena Martinez; Elizabeth Jacobs; Erin L. Ashbeck; David S. Alberts; Peter Lance
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