Issues

The cover image is a photomicrograph (200X) showing specific induction of apoptosis in KRAS-induced lung tumor cells in LSL-KRAS-G12D mice treated with tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) plus Smac/DIABLO (Smac) mimic. LSL-KRAS-G12D mice were infected with AdenoCre and treated six weeks later with TRAIL (3 mg/kg) plus Smac mimic (3 mg/kg) for three cycles within one week. Three days after the last treatment, the lung sections were stained with an anti-cleaved caspase 3 antibody, which reveals apoptosing cells. Caspase 3 staining appears in adenoma cells (redorange, left), whereas the adjacent normal lung epithelial cells are devoid of caspase 3 staining (the image was graphically enhanced for aesthetic purposes). See articles by Huang et al. (beginning on page 666) and Meyskens and Gerner (beginning on page 628) for more information.