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1 April 2011
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Cover Image
Cover Image
The cover image is a photomicrograph of SKOV3ip1 ovarian cancer cells (400X magnification; courtesy of Nicholas B. Jennings) with an increased level of phosphorylated focal adhesion kinase Y397 (pFAKY397; red) localized to focal adhesions following treatment with norepinephrine. pFAKY397 and actin (green) show up under immunofluorescence staining. Exposure of cancer cells to stress hormones such as norepinephrine leads to b2 adrenergic receptor–mediated activation/phosphorylation of FAKY397, leading in turn to anoikis avoidance (anoikis is programmed cell death induced when anchorage-dependent cells detach from the surrounding extracellular matrix) and metastasis. See article by Sood and Lutgendorf (beginning on page 481) for more information. - PDF Icon PDF LinkTable of Contents
ISSN 1940-6207
EISSN 1940-6215
Issue Sections
Perspectives
Minireview
Reviews
Brief Communication
Phase IIA Trial Testing Erlotinib as an Intervention against Intraductal Pancreatic Mucinous Neoplasms
Steven Lipkin; John Lee; David Imagawa; Stephen M. Hewitt; Chris Tucker; Jason A. Zell; Vanessa Wong; Angela Garcia; Rachel Gonzalez; Gary Della Zanna; Ellen Richmond; L.M. Rodriguez; M Bigg; F Schnoll-Sussmans; Frank Meyskens
Research Articles
Physical Activity and Survival in Postmenopausal Women with Breast Cancer: Results from the Women's Health Initiative
Melinda L. Irwin; Anne McTiernan; JoAnn E. Manson; Cynthia A. Thomson; Barbara Sternfeld; Marcia L. Stefanick; Jean Wactawski-Wende; Lynette Craft; Dorothy Lane; Lisa W. Martin; Rowan Chlebowski
Altered Folate Availability Modifies the Molecular Environment of the Human Colorectum: Implications for Colorectal Carcinogenesis
Petr Protiva; Joel B. Mason; Zhenhua Liu; Michael E. Hopkins; Celeste Nelson; James R. Marshall; Richard W. Lambrecht; Swaroop Pendyala; Levy Kopelovich; Myungjin Kim; Steven H. Kleinstein; Peter W. Laird; Martin Lipkin; Peter R. Holt
Induction of Retinoid X Receptor Activity and Consequent Upregulation of p21WAF1/CIP1 by Indenoisoquinolines in MCF7 Cells
Eun-Jung Park; Tamara P. Kondratyuk; Andrew Morrell; Evgeny Kiselev; Martin Conda-Sheridan; Mark Cushman; Soyoun Ahn; Yongsoo Choi; Jerry J. White; Richard B. van Breemen; John M. Pezzuto
Meeting Report
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