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1 December 2011
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Cover Image
Cover Image
The cover image is a photomicrograph (200X magnification) of mouse skin stained with antibody to activating transcription factor 6 alpha (ATF6α; red). Nuclei were counterstained with 4′,6-diamidino-2-phenylindole (DAPI; blue). The color images were taken separately using an Olympus BX 51 Fluorescent microscope and then merged. When unfolded protein response (UPR) is activated, ATF6α translocates from endoplasmic reticulum (ER) membrane to the Golgi apparatus, where it undergoes cleavage by site-1 protease (S1P) and S2P. Cleaved ATF6α migrates to the nucleus (violet, reflecting its overlay with DAPI blue staining) and induces transcription of UPR target genes. New work reported in this issue of the journal found that sub-chronic arsenic exposure activated reactive oxygen species (ROS)- dependent UPR signaling pathways (including the ATF6α pathway), which enhanced inflammation in murine skin. UPR signaling is under intensive investigation in inflammatory diseases and cancers. See article by Li et al. (beginning on page 2101) for more information. - PDF Icon PDF LinkTable of Contents
ISSN 1940-6207
EISSN 1940-6215
Issue Sections
Perspective
Research Articles
Mechanistic Contribution of Ubiquitous 15-Lipoxygenase-1 Expression Loss in Cancer Cells to Terminal Cell Differentiation Evasion
Micheline J. Moussalli; Yuanqing Wu; Xiangsheng Zuo; Xiu L. Yang; Ignacio Ivan Wistuba; Maria G. Raso; Jeffrey S. Morris; Jessica L. Bowser; John D. Minna; Reuben Lotan; Imad Shureiqi
Revisit of Field Cancerization in Squamous Cell Carcinoma of Upper Aerodigestive Tract: Better Risk Assessment with Epigenetic Markers
Yi-Chia Lee; Hsiu-Po Wang; Cheng-Ping Wang; Jenq-Yuh Ko; Jang-Ming Lee; Han-Mo Chiu; Jaw-Town Lin; Satoshi Yamashita; Daiji Oka; Naoko Watanabe; Yasunori Matsuda; Toshikazu Ushijima; Ming-Shiang Wu
Changes in Breast Density and Circulating Estrogens in Postmenopausal Women Receiving Adjuvant Anastrozole
Tatiana M. Prowell; Amanda L. Blackford; Celia Byrne; Nagi F. Khouri; Mitchell Dowsett; Elizabeth Folkerd; Karineh S. Tarpinian; Pendleton P. Powers; Laurie A. Wright; Michele G. Donehower; Stacie C. Jeter; Deborah K. Armstrong; Leisha A. Emens; John H. Fetting; Antonio C. Wolff; Elizabeth Garrett-Mayer; Todd C. Skaar; Nancy E. Davidson; Vered Stearns
Alcohol Intake and Colorectal Cancer Risk by Molecularly Defined Subtypes in a Prospective Study of Older Women
Anthony A. Razzak; Amy S. Oxentenko; Robert A. Vierkant; Lori S. Tillmans; Alice H. Wang; Daniel J. Weisenberger; Peter W. Laird; Charles F. Lynch; Kristin E. Anderson; Amy J. French; Robert W. Haile; Lisa J. Harnack; Susan L. Slager; Thomas C. Smyrk; Stephen N. Thibodeau; James R. Cerhan; Paul J. Limburg
The Histone Demethylase JMJD2B Plays an Essential Role in Human Carcinogenesis through Positive Regulation of Cyclin-Dependent Kinase 6
Gouji Toyokawa; Hyun-Soo Cho; Yukiko Iwai; Masanori Yoshimatsu; Masashi Takawa; Shinya Hayami; Kazuhiro Maejima; Noriaki Shimizu; Hirotoshi Tanaka; Tatsuhiko Tsunoda; Helen I. Field; John D. Kelly; David E. Neal; Bruce A.J. Ponder; Yoshihiko Maehara; Yusuke Nakamura; Ryuji Hamamoto
Phase II Prospective Randomized Trial of a Low-Fat Diet with Fish Oil Supplementation in Men Undergoing Radical Prostatectomy
William J. Aronson; Naoko Kobayashi; R. James Barnard; Susanne Henning; Min Huang; Patricia M. Jardack; Bingrong Liu; Ashley Gray; Junxiang Wan; Ramdev Konijeti; Stephen J. Freedland; Brandon Castor; David Heber; David Elashoff; Jonathan Said; Pinchas Cohen; Colette Galet
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