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1 July 2010
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Cover Image
Cover Image
The cover features a histology section of a biopsy specimen from an oral premalignant lesion (OPL) stained with an epidermal growth factor receptor (EGFR)–specific antibody and counterstained with hematoxylin (200x magnification; Ariol-platform image courtesy of Sufi Thomas). The strong expression of EGFR (brown) predominantly occurs in the basal layer of the epithelium; connective tissue does not express EGFR (mottled blue). EGFR abnormalities are associated with oral tumorigenesis and progression. As reported in this issue of the journal, EGFR-expression and gene copy-number changes were evaluated (immunohistochemistry for expression, fluorescence in situ hibridization for copy number) as markers of an OPL's increased risk for progressing to oral cancer in a randomized controlled clinical trial. See articles by Benchekroun et al. (beginning on page 800 ) and Rosin and Califano (beginning on page 797 ) for more information. - PDF Icon PDF LinkTable of Contents
ISSN 1940-6207
EISSN 1940-6215
Issue Sections
Perspective
Research Articles
Epidermal Growth Factor Receptor Expression and Gene Copy Number in the Risk of Oral Cancer
Mohammed Taoudi Benchekroun; Pierre Saintigny; Sufi M. Thomas; Adel K. El-Naggar; Vassiliki Papadimitrakopoulou; Hening Ren; Wenhua Lang; You-Hong Fan; Jianhua Huang; Lei Feng; J. Jack Lee; Edward S. Kim; Waun Ki Hong; Faye M. Johnson; Jennifer R. Grandis; Li Mao
Serum Cytokine Analysis in a Positive Chemoprevention Trial: Selenium, Interleukin-2, and an Association with Squamous Preneoplastic Disease
Mark J. Roth; Hormuzd A. Katki; Wen-Qiang Wei; You-Lin Qiao; Rachel Bagni; Guo-Qing Wang; Denise Whitby; Zhi-Wei Dong; Mitchell H. Gail; Paul J. Limburg; Carol A. Giffen; Philip R. Taylor; Sanford M. Dawsey
Optical Measurement of Rectal Microvasculature as an Adjunct to Flexible Sigmoidosocopy: Gender-Specific Implications
Hemant K. Roy; Andrew J. Gomes; Sarah Ruderman; Laura K. Bianchi; Michael J. Goldberg; Valentina Stoyneva; Jeremy D. Rogers; Vladimir Turzhitsky; Young Kim; Eugene Yen; Mohammed Jameel; Andrej Bogojevic; Vadim Backman
Meat Consumption, Nonsteroidal Anti-Inflammatory Drug Use, and Mortality among Colorectal Cancer Patients in the California Teachers Study
Jason A. Zell; Argyrios Ziogas; Leslie Bernstein; Christina A. Clarke; Dennis Deapen; Joan A. Largent; Susan L. Neuhausen; Daniel O. Stram; Giske Ursin; Hoda Anton-Culver
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